A trainer notices Stewie struggling with barbells and offers steroids.
Peter injects the drugs into Stewie, who becomes incredibly buff and develops an aggressive personality, much to the horror of his family. As time passes, Stewie's drugs gradually wear off, much to his shock. Stewie jumps out of his bedroom window to avoid Brian's wrath, only to have his loosened skin help him glide to safety.
The episode featured many of the show's recurring guest voice actors including: Alexandra Breckenridge, Chris Cox, Ralph Garman, and writers Danny Smith, Alec Sulkin, and John Viener also made minor appearances.
Paul Sorvino and Chazz Palminteri are seen acting in a fictional movie called "Distracting Trumpet". Club gave a much more critical review giving the episode a grade of a C.Meanwhile, Chris becomes the fake boyfriend of popular student Connie D'Amico.He begins to like her, and the two begin a serious relationship, leading him to become mean and self-centered towards everyone around him.As a result, Chris' popularity increases at school, which leads to accolades by the jocks, cheerleaders, and other socially powerful students.Meg tries to use the relationship to gain popularity herself, only to find herself snubbed off by Chris' newfound shallowness.After Stewie's steroids injection wears off and he jumps out the bedroom window, the music playing is from the cartoon The Rocky and Bullwinkle Show. Heisler stated that neither of the storylines "held any water", because they were "ridiculously short".He also commented: "I'm starting to wonder if this show is even watchable anymore – 18 minutes of filler, 45 seconds of inspired silliness." The Parents Television Council, a frequent critic of Family Guy, named "Stew-Roids" its "Worst TV Show of the Week" for the week ending August 28, 2009; the review was based on a repeat airing.In the process Stewie develops a macho stature as well as an obnoxious behavior, picking on Brian and others around him.However, there was a sub-plot which took up almost as much time as the main plot.Meanwhile, Connie D'Amico learns what it is like to walk in Meg's shoes after she asks Chris out (intending it to be a short-lived relationship), the relationship actually goes somewhere then, at a party at the Griffins (where Meg is not invited), Chris breaks up with Connie to date two other girls.The title is based on the family of drugs called steroids that is used medically to rebuild body tissue and is illegally used by athletics to increase muscle tissue, but has adverse mental and physical consequences that include dependence and aggression. The jokes have been redundant and the cutaway gags have been too long.